Adrian Britschgi

Institution: Friedrich Miescher Institute for Biomedical Research

Address:

Maulbeerstrasse 66 WRO-1066.2.22 CH-4058 Basel Switzerland

Email: adrian.britschgi@fmi.ch

Group website: www.fmi.ch/research/groupleader/?group=117

Phone: 0041786024458

Research interests:

Oncogenic signaling and mechanisms of metastasis Mechanisms of resistance to targeted therapy Cell fate regulation in the mammary gland

Selected publications:

Koren S., Reavie L., Pinto do Couto J., De Silva D., Stadler M, Roloff T., Britschgi A., Eichlisberger T., Kohler H., Aina O., Cardiff R.D. and Bentires-Alj M.: PIK3CAH1047R induces mammary cell plasticity and multi-lineage tumors irrespective of the cell-of-origin. Nature 525, 114–118, 2015. Sausgruber N, Coissieux M-M, Britschgi A, Wyckoff J, Aceto N, Leroy C, Voshol H, Bonenfant D and Bentires-Alj, M: Tyrosine phosphatase SHP2 increases cell motility in triple negative breast cancer through the activation of SRC-family kinases. Oncogene: 34(17):2272-8, 2014. Duss S, Brinkhaus H, Britschgi A, Cabuy E, Frey DM, Schaefer DJ and Bentires-Alj M: Mesenchymal precursor cells maintain the differentiation and proliferation potentials of breast epithelial cells. Breast Cancer Research: 16(3), 2014. Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, Rebhan M, Raman P, Guy CT, Wetzel K, George E, Popa MO, Lilley S, Choudhury H, Gosling M, Wang L, Fitzgerald S, Borawski J, Baffoe J, Labow M, Gaither LA, Bentires-Alj M.: Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. PNAS: 110(11), 2013. Britschgi A, Radimerski T, Bentires-Alj M.: Targeting PI3K, HER2 and the IL-8/JAK2 axis in metastatic breast cancer: which combination makes the whole greater than the sum of its parts? Drug Resistance Updates 16(3-5):68-72, 2013. Britschgi A, Andraos R, Brinkhaus H, Klebba I, Romanet V, Müller U, Murakami M, Radimerski T, Bentires-Alj M.: JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: a rationale for cotargeting these pathways in metastatic breast cancer. Cancer Cell: 22(6):796-811, 2012 Duss S, Britschgi A, Bentires-Alj M.: Hippo inactivation feeds tumor-initiating cells. Breast Cancer Research, 14(4):318, 2012. Balavenkatraman KK, Aceto N, Britschgi A, Mueller U, Bence KK, Neel BG, Bentires-Alj M.: Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance. Molecular Cancer Research: (10):1377-84, 2011.

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