Charlotte K Y Ng

Institution: University Hospital Basel

Address:

Schönbeinstrasse 40, Basel

Email: kiuyancharlotte.ng@usb.ch

Research interests:

Cancer genomics, bioinformatics, inter and intra-tumor heterogeneity, precision medicine, massively parallel (next-generation) sequencing

Selected publications:

Piscuoglio S*, Ng CKY*, Murray M*, Guerini-Rocco E, Martelotto LG, Geyer FC, Bidard F-C, Berman S, Fusco N, Sakr RA, Eberle CA, De Mattos-Arruda L, Macedo GS, Akram M, Baslan T, Hicks JB, King TA, Brogi E, Norton L, Weigelt B, Hudis CA, Reis-Filho JS. The Genomic Landscape of Male Breast Cancers. Clin Cancer Res. In press. Piscuoglio S*, Ng CKY*, Murray M, Burke KA, Edelweiss M, Geyer FC, Macedo GS, Inagaki A, Papanastasiou A, Martelotto LG, Marchio C, Lim RS, Ioris RA, Nahar PK, De Bruijn I, Smyth L, Akram M, Ross D, Norton L, Solit DB, Baselga J, Brogi E, Ladanyi M, Weigelt B, Reis-Filho JS. TERT promoter hotspot mutations and TERT gene amplification in Phyllodes tumors of the breast. J Pathol. 2016; 238(4):508-18. Garcia-Murillas I, Schiavon G, Weigelt B, Ng C, Hrebien S, Cutts, RJ, Osin P, Nerukar A, Kozarewa I, Armisen Garrido J, Dowsett M, Reis-Filho JS, Smith IE, Turner NC. Mutation tracking in circulating tumor DNA to predict relapse in early breast cancer. Sci Transl Med. 2015; 7(302):302ra133. Ng CKY*, Schultheis AM*, Bidard F-C, Weigelt B, Reis-Filho JS. Breast Cancer Genomics from Microar- rays to Massively Parallel Sequencing: Paradigms and New Insights. J Natl Cancer Inst. 2015; 107(5):djv015. Bidard F-C, Ng CKY, Cottu P, Piscuoglio S, Escalup L, Sakr RA, Reyal F, Mariani P, Lim RS, Wang L, Norton, L, Servois V, Sigal B, Vincent-Salomon A, Weigelt B, Pierga J-Y, Reis-Filho JS. Response to dual HER2 blockade in a patient with HER3-mutant metastatic breast cancer. Annals Oncol. 2015; 26(8):1704-9. Ng CKY*, Martelotto LG*, Gauthier A*, Wen H-C*, Piscuoglio S, Lim RS, Cowell CF, Wilkerson PM, Wai P, Rodrigues DN, Arnould L, Geyer FC, Bromberg SE, Lacroix-Tikri M, Penault-Llorca F, Giard S, Sastre-Garau X, Natrajan R, Norton L, Cottu PH, Weigelt B, Vincent-Salomon A, Reis-Filho JS. Genomic characterisation of inva- sive breast cancers with heterogeneous HER2 gene amplification. Genome Biol. 2015; 16(1):107. Martelotto LG*, Ng CKY*, De Filippo MR, Zhang Y, Piscuoglio S, Shen R, Norton L, Reis-Filho JS, Weigelt B. Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mu- tations. Genome Biol. 2014; 15(10):484. Ng CKY*, Weigelt B*, Bidard F-C, Lemetre C, A’hern R, Swanton C, Shen R, Reis-Filho JS. Predictive performance of microarray gene signatures: impact of tumor heterogeneity and multiple mechanisms of drug resistance. Cancer Res. 2014; 74(11):2946-61.

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