Enni Markkanen

Institution: University of Zurich


Institute of Veterinary Pharmacology and Toxicology Vetsuisse Faculty Winterthurerstr. 260 8057 Zürich

Email: enni.markkanen@vetpharm.uzh.ch

Group website: www.vpt.uzh.ch/en/research/groupmarkkanen.html

Phone: +41 44 635 8770

Research interests:

Breast cancer Cancer research Canine mammary tumours Comparative oncology Tumour stroma Tumour microenvironment DNA damage DNA repair

Selected publications:

1. Ettlin, J., Clementi, E., Amini, P., Malbon, A., and Markkanen, E.: Analysis of Gene Expression Signatures in Cancer-Associated Stroma from Canine Mammary Tumours Reveals Molecular Homology to Human Breast Carcinomas. Int J Mol Sci., 2017; doi: 10.3390/ijms18051101 2. Pfister, S. X., Markkanen, E., Jiang, Y., Sarkar, S., Woodcock, M., Pai, C., Zalmas, L. P., Orlando, G., Dianov, G.L., Ying, S., La Thangue, N. B., D’Angiolella, V., Ryan, A., and Humphrey, T. C.: Inhibiting WEE1 selectively kills histone H3K36me3-deficient cancers by dNTP starvation. Cancer Cell. 2015 Oct 20. pii: S1535-6108(15)00346-3. 3. Markkanen, E., Fischer, R., Ledentcova, M., Kessler, B.M., and Dianov, G.L.: Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability. Nucleic Acids Res., 2015. doi: 10.1093/nar/gkv222 4. Markkanen, E.*, Castrec, B.*, Villani, G., and Hübscher, U.: A switch between DNA polymerases δ and λ promotes error-free bypass of 8-oxo-G lesions. Proc Natl Acad Sci U S A 2012, 109(50):20401-6. doi: 10.1073/pnas.1211532109. * contributed equally 5. Markkanen, E., van Loon, B., Ferrari, Parsons, J.L., Dianov, G. and Hübscher, U.: Regulation of oxidative DNA damage repair by DNA polymerase lambda and MutYH by cross-talk of phosphorylation and ubiquitination. Proc Natl Acad Sci U S A 2012, 109(2):437-42. doi: 10.1073/pnas.1110449109.

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