Fabienne Meier-Abt

Institution: Universitätsspital Basel

Address:

Spitalstrasse 21/ Petersgraben 4 4031 Basel

Email: fabienne.meier-abt@usb.ch

Research interests:

- Effects of systemic hormones and local growth factors on stem cells, cancer stem cells and solid tumors.

- Systemic analyses applied to tumor biology and its translation into personalized treatment approaches (personalized medicine).

- Understanding the mechanisms underlying the natural protection against solid tumors.

Selected publications:

1) Meier-Abt F, Brinkhaus H, and M Bentires-Alj. Early but not late pregnancy induces life-long reductions in the proportion of mammary progesterone sensing cells and epithelial Wnt signaling. – Breast Cancer Res. 16: 402, 2014

2) Meier-Abt F and M Bentires-Alj. How pregnancy at early age protects against breast cancer. – Trends Mol Med. 13: 143-153, 2014

3) Meier-Abt F, Milani E, Roloff T, Brinkhaus H, Duss S, Meyer DS, Klebba I, Balwierz P, van Nimwegen E, and M Bentires-Alj. Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium. – Breast Cancer Res. 15: R36, 2013

4) Meier-Abt F and B Strasser. Balancing safety and availability: a historical perspective on the pace of drug approval, 1950s-2009. – Yale J Biol Med. 82 (4): 181-229, 2009

5) Meier-Abt F, Hammann-Haenni A, B Stieger, N Ballatori, and J Boyer. The organic anion transporting polypeptide 1d1 (Oatp 1d1) mediates hepatocellular uptake of phalloidin and microcystin into skate liver. – Toxicol Appl Pharmacol. 218 (3): 274-9, 2007

6) Meier-Abt F, Y Mokrab, and K Mizuguchi. Organic anion transporting polypeptides of the OATP/SLCO superfamily: identification of new members in non-mammalian species, comparative modelling and a potential transport mode. – J Membr Biol. 208 (3): 213-27, 2005

7) Meier-Abt F, H Faulstich, and B Hagenbuch. Identification of phalloidin uptake systems of rat and human liver. – Biochim Biophys Acta 1664: 64-69, 2004

8) Hagenbuch B, MG Ismair, W Fischer, F Meier-Abt, GA Kullak-Ublick, and PJ Meier. Identification of specific substrates for some multispecific organic anion transporting polypeptides. – Nova Acta Leopoldina 87: 199-204, 2003

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