Institution: University of Bern, Theodor Kocher Institute
Address:
Freiestrasse, 1 CH-3012, Bern Switzerland
Email: federica.moalli@tki.unibe.ch
Group website: www.tki.unibe.ch/content/research/jens_stein/topic/index_eng.html
Phone: +41 (0) 316314161
Research interests:
In our laboratory we use intravital two-photon microscopy (2PM) and whole-mount 3D lymph node (LN) imaging of tumor-draining LNs of immunocompetent mice, to analyse the distribution of tumor derived antigens in a B16 melanoma model. Another on going project in the lab is focused to study the effect of downregulating negative modulators in adoptively transferred CD8+ T cells on their capacity of tumor killing in a spontaneously arising murine PyMT-driven breast cancer tumor model, taking advantage of our expertise in mammary gland imaging.
Selected publications:
Intravital and whole-organ imaging reveals capture of melanoma-derived antigen by lymph node subcapsular macrophages leading to widespread deposition on follicular dendritic cells. Moalli F, Proulx ST, Schwendener R, Detmar M, Schlapbach C, Stein JV. Front Immunol. 2015 Mar 13;6:114. doi: 10.3389/fimmu.2015.00114. eCollection 2015.
