Florent Beaufils

Institution: PIQUR Therapeutics AG

Address:

Hochbergerstrasse 60C, 4057 Basel

Email: florent.beaufils@piqur.com

Group website: www.piqur.com

Phone: 0616953139

Research interests:

Oncology Drug Discovery, PI3K/mTOR inhibitors

Selected publications:

Thomas Bohnacker, Florent Beaufils, Andrea E. Prota, John E. Burke, Anna Melone, Alison J. Inglis, Ludovico Fusco, Vladimir Cmiljanovic, Natasa Cmiljanovic, Denise Rageot, Katja Bargsten, Gonzalo Saez-Calvo, Olivier Pertz, Amol B. Aher, Anna Akhmanova, Fernando J. Diaz, Doriano Fabbro, Marketa Zvelebil, Roger L. Williams, Michel O. Steinmetz, Matthias P. Wymann. BKM120-mediated G2 arrest: Structural and functional segregation of off-target action and PI3K inhibition. [abstract]. Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 671. Vladimir Cmiljanovic, Natasa Cmiljanovic, Romina Marone, Florent Beaufils, Xuxiao Zhang, Marketa Zvelebil, Paul Hebeisen, Marc Lang, Juergen Mestan, Anna Melone, Thomas Bohnacker, Eugenio Gaudio, Chiara Tarantelli, Francesco Bertoni, Reto Ritschard, Vincent Pretre, Andreas Wicki, Doriano Fabbro, Petra Hillmann, Roger Williams, Bernd Giese, Matthias P. Wymann. PQR309: Structure-based design, synthesis and biological evaluation of a novel, selective, dual pan-PI3K/mTOR inhibitor. [abstract]. Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2664. M. Zimmermann, R. Cal, E. Janett, V. Hoffmann, C. G. Bochet, E. Constable, F. Beaufils, M. P. Wymann Cell-Permeant and Photocleavable Chemical Inducer of Dimerization Ang. Chem. Int. Ed. 2014, Ang. Chem. Int. Ed. 2014, 53, 4717-4720. D. Erhart, M. Zimmermann, O. Jacques, M. B. Wittwer, B. Ernst, E. Constable, M. Zvelebil, F. Beaufils, M. P. Wymann. Chemical Development of Intracellular Protein Heterodimerizers Chemistry&Biology, 2013, 15, 128-136. F. Kampmeier, M.Ribbert, T. Nachreiner, S. Dembski, F. Beaufils, A. Brecht, S. Barth. Site Specific, Covalent Labeling of Recombinant Antibody Fragments via Fusion to an Engineered Version of 6-O-methylguanine DNA Alkyltransferase. Bioconjugate Chem., 2009, 20 (5), 1010-1015. A. Fuerstner, L. Bouchez, J.-A. Funel, V. Liepins, F.-H. Poree, R. Gilmour, F. Beaufils, D. Laurich, M. Tamiya. Total Synthesis of Amphidinolide H and G. Ang. Chem. Int. Ed. 2007, 46 (48), 9265-9270. A. Gautier, A. Juillerat, C. Heinis, I. R. Correa Jr., M. Kindermann, F. Beaufils, K. Johnsson. An Engineered Protein Tag for Multiprotein Labeling in Living Cells, Chemistry&Biology, 2008, 15, 128. L. F. Mottram, E. Maddox, M. Schwab, F. Beaufils, B. R. Peterson. A Concise Synthesis of the Pennsylvania Green Fluorophore and Labelling of Intracellular Targets. Org. Lett. 2007, 9 (21), 3741–3744.

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