Francis Jacob

Institution: University Hospital Basel


Lab 420 Hebelstrasse 20 4031 Basel Switzerland


Group website:

Phone: 0041613286986

Research interests:

Metastasis, Tumor-specific glycans, anti-glycan antibodies, triple-negative breast cancer, assay development, tumor biomarker, genome-editing

Selected publications:

Anugraham, M., Jacob, F., Everest-Dass, A.V., Schötzau, A., Hacker, N.F., Fink, D., Packer, N.H., Heinzelmann-Schwarz, V. Tissue glycomics identifies different tumour sites in advanced serous adenocarcinoma. Accepted for publication Molecular Oncology IF 5.314 original article Kohler, R.S., Kettelhack, H., Knipprath-Meszaros, A., Fedier, A., Schötzau, Jacob, F., Heinzelmann-Schwarz, V. MELK expression in ovarian cancer correlates with poor outcome and its inhibition by OTSSP167 abrogates proliferation and viability of ovarian cancer cells. (2017) Gynecological Oncology 145(1): 159-166 doi: 10.1016/j.ygyno.2017.02.016 IF 4.959 original article Alam, S., Anugraham, M., Huang, Y.L., Kohler, R., Hettich, T., Winkelbach, K., Grether, Y., Lopez, M.N., Khasbiullina, N., Bovin, N.V., Schlotterbeck, G., Jacob, F., Altered (neo-) lacto series glycolipid biosynthesis impairs α2-6 sialylation on N-glycoproteins in ovarian cancer cells. (2017) Scientific Reports 7 45367 doi:10.1038/srep45367 IF 4.259 original article Kohler, R., Anugraham, M., Lopez, M.N., Xiao, C., Schötzau, A., Hettich, T., Schlotterbeck, G., Fedier, A., Heinzelmann-Schwarz, V.A.*, Jacob, F*, Epigenetic activation of MGAT3 and corresponding bisecting GlcNAc shortens the survival of cancer patients. (2016) Oncotarget doi: 10.18632/oncotarget.10543. IF 5.168 original article Alam, S., Fedier, A., Kohler, R., Jacob, F. Glucosylceramide synthase inhibitors differentially affect glycosphingolipids. (2015) Glycobiology 25 (4) 351-356 IF 3.112 original article Anugraham, M.*, Jacob, F.*, Dass, A., Heinzelmann-Schwarz, V.A., Packer, N.H. (2014) Epithelial ovarian cancer biomarkers: Novel identification of specific epitopes in plasma membrane N-glycans from ovarian cells. Molecular and Cellular Proteomics 13(9): 2213-2232 IF 6.540 original article Jacob, F., Anugraham, M., Pochechueva, T., Tse, B.W.C., Alam, S., Guertler, R., Bovin, N.V., Fedier, A., Hacker, N.F., Huflejt, M.E., Packer, N., Heinzelmann-Schwarz, V.A. (2014) The glycosphingolipid P1 is an ovarian cancer-associated carbohydrate antigen involved in migration. British Journal of Cancer doi: 10.1038/bjc.2014.455 IF 6.176 original article Jacob, F., Goldstein, D.R., Bovin, N.V., Pochechueva, T., Spengler, M, Caduff, R., Fink, D., Vuskovic, M.I., Huflejt, M.E., Heinzelmann-Schwarz, V. (2012) Serum antiglycan antibody detection on non-mucinous epithelial ovarian cancers using printed glycan array. International Journal of Cancer 130(1): 138-146 doi: 10.1002/ijc.26002 IF 6.513 original article

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