Gerhard Christofori

Institution: Department of Biomedicine, University of Basel

Address:

Mattenstrasse 28 4058 Basel

Email: gerhard.christofori@unibas.ch

Group website: biomedizin.unibas.ch/nc/research/research-group-details/home/researchgroup/tumor-biology/

Phone: 061 267 3562

Research interests:

tumor angiogenesis and lymphangiogenesis, cell adhesion, cell migration and invasion, metastasis mouse models, signal transduction transcritional control

Selected publications:

Perl, A.-K., Wilgenbus, P., Dahl, U., Semb, H., and Christofori, G. (1998) A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392, 190-193.

Perl, A.-K., Dahl, U., Wilgenbus, P., Cremer, H., Semb, H., and Christofori, G. (1999) Reduced expression of neural cell adhesion molecule (N-CAM) induces metastatic dissemination of pancreatic β tumor cells. Nature Med. 5, 286-291.

Cavallaro, U., Niedermeyer, J., Fuxa, M., and Christofori, G. (2001) N-CAM modulates integrin-mediated cell adhesion by activating FGF receptor signalling. Nature Cell Biol. 3, 650-657.

Wicki, A., Lehembre, F., Wick, N., Hantusch, B., Kerjaschki D., and Christofori, G. (2006) Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the cytoskeleton. Cancer Cell 9, 261-272.

Kren, A., Baeriswyl, V., Lehembre, F., Wunderlin, C., Strittmatter, K., Antoniadis, H., Fässler, R., Cavallaro, U., and Christofori, G. (2007) Increased tumor cell dissemination and cellular senescence in the absence of β1-integrin function. EMBO J. 26, 2832-2842.

Lehembre, F., Yilmaz, M., Wicki, A., Schomber, T., Strittmatter, K., Ziegler, D., Kren, A., Went, P., Derksen, P., Berns, A., Jonkers, J., and Christofori, G. (2008) NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin. EMBO J. 27, 2603-2615.

Yilmaz, M., Maaß, D., Tiwari, N., Waldmeier, L., Schmidt, P., Lehembre, F., and Christofori, G. (2011) Dlx2 protects from TGFβ-induced cell-cycle arrest and apoptosis. EMBO J. 30, 4489-4499.

Tiwari, N., Tiwari, V.K., Waldmeier, L., Balwierz, P.J., Arnold, P., Pachkov, M., Meyer-Schaller, N., Schübeler, D., van Nimwegen, E., and Christofori, G. (2013) Sox4 is a master regulator of epithelial-mesenchymal transition (EMT) by controlling Ezh2 expression and epigenetic reprogramming. Cancer Cell 23, 768-783.

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