Gertraud Orend

Institution: INSERM U1109 - MN3T


3 avenue Molère 67200 Strasbourg


Group website:

Phone: 0033 (0) 3 88 27 53 55

Research interests:

Role of tenascin-C in cancer including breast cancer. Development of syngeneic breast cancer model with defined tenascin-C expression in an immune competent host to identify the impact of tenascin-c on anti-tumor immunity.

Selected publications:

Saupe F, Schwenzer A, Jia Y, Gasser I, Spenlé C, Langlois B, Kammerer M, Lefebvre O, Hlushchuk R, Rupp T, Marko M, Van der Heyden M, Cremel G, Arnold C, Klein A, Simon-Assmann P, Djonov V, Neuville-Méchine A, Esposito I, Slotta-Huspenina J, Janssen K-P, de Wever O, Christofori G, Hussenet T, Orend G, 2013. Tenascin-C downregulates Wnt inhibitor Dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model. Cell Reports 5, 482-92. Chiquet-Ehrismann R*, Orend G*, Chiquet M*, Tucker RP*, Midwood KS*, 2014. Tenascins in stem cell niches, Matrix Biology (invited contribution for the special Issue on Matricellular Proteins), 37: 112-23. * equal contribution Arpel A, Sawma P, Spenlé C, Garnier N, Velásquez-Quesada I, Hussenet T, Aci-Sèche S, Baumlin N, Duneau JP, Genest M, Brasse D, Hubert P, Crémel G, Orend G, Laquerrière P, Bagnard D, 2014. Transmembrane domain targeting peptide antagonizing ErbB2/Neu inhibits breast tumor growth and metastasis, Cell Reports, 8, 1714-1721. Langlois B, Saupe F, Rupp T, Arnold C, Van der Heyden M, Orend G*, Hussenet T*, 2014. AngioMatrix, a gene expression signature of the tumor angiogenic switch-specific extracellular matrix, correlates with poor prognosis for human glioblastoma and colorectal cancer patients, Oncotarget, 5, 10529-10545. * corresponding authors Spenlé C, Gasser I, Saupe F, Janssen KP, Arnold C, Klein A, van der Heyden M, Mutterer J, Neuville-Méchine A, Chenard MP, Guenot D, Esposito I, Slotta-Huspenina J, Amburtsumian N, Simon-Assmann P, Orend G. 2015. Spatial organization of the tenascin-C microenvironment in experimental and human cancer, Cell Adh Migr, 9, 4 - 13. Spenlé C, Saupe F, Midwood K, Burckel H, Noel G, Orend G, 2015. Tenascin-C: exploitation and collateral damage in cancer management, special issue on "Tenascins: defining their roles in tissue homeostasis and cancer", Cell Adh and Migr, 9, 141 - 153. Tierney MT, Gromova A, Boscolo Sesillo F, Sala D, Spenlé C, Orend G, Sacco A, 2016. Autonomous microenvironmental remodeling controls fetal muscle stem cell fate. Cell Reports, doi: 10.1016/j.celrep.2016.01.072. [Epub ahead of print]

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