Girieca Lorusso

Institution: UNIFR Dept Medicine, Pathology


Chemin du Musèe, 14 1700 Fribourg


Group website:

Phone: 026-300-8567

Research interests:

breast cancer metastasis metastasis organotropism tumor microenvironment

Selected publications:

Fragment N2, a caspase-3-generated RasGAP fragment, inhibits breast cancer metastatic progression. Barras D, Lorusso G, Lhermitte B, Viertl D, Rüegg C, Widmann C. Int J Cancer. 2014 Jul 1;135(1):242-7. doi: 10.1002/ijc.28674. Epub 2014 Mar 4. PMID: 24347041 2. Inhibition of cell migration and invasion mediated by the TAT-RasGAP317-326 peptide requires the DLC1 tumor suppressor. Barras D, Lorusso G, Rüegg C, Widmann C. Oncogene. 2014 Oct 30;33(44):5163-72. doi: 10.1038/onc.2013.465. Epub 2013 Nov 11. PMID: 24213569 3. Inhibition of the Kit ligand/c-Kit axis attenuates metastasis in a mouse model mimicking local breast cancer relapse after radiotherapy. Kuonen F, Laurent J, Secondini C, Lorusso G, Stehle JC, Rausch T, Faes-Van't Hull E, Bieler G, Alghisi GC, Schwendener R, Andrejevic-Blant S, Mirimanoff RO, Rüegg C. Clin Cancer Res. 2012 Aug 15;18(16):4365-74. Epub 2012 Jun 18. PMID: 22711708 Free Article 4. New insights into the mechanisms of organ-specific breast cancer metastasis. Lorusso G, Rüegg C. Semin Cancer Biol. 2012 Jun;22(3):226-33. doi: 10.1016/j.semcancer.2012.03.007. Epub 2012 Apr 5. Review. PMID: 22504658 5. Proangiogenic factor PlGF programs CD11b(+) myelomonocytes in breast cancer during differentiation of their hematopoietic progenitors. Laurent J, Hull EF, Touvrey C, Kuonen F, Lan Q, Lorusso G, Doucey MA, Ciarloni L, Imaizumi N, Alghisi GC, Fagiani E, Zaman K, Stupp R, Shibuya M, Delaloye JF, Christofori G, Ruegg C. Cancer Res. 2011 Jun 1;71(11):3781-91. doi: 10.1158/0008-5472.CAN-10-3684. Epub 2011 Apr 20. PMID: 21507936 Free Article 6. The tumor microenvironment and its contribution to tumor evolution toward metastasis. Lorusso G, Rüegg C. Histochem Cell Biol. 2008 Dec;130(6):1091-103. doi: 10.1007/s00418-008-0530-8. Epub 2008 Nov 6. Review. PMID: 18987874 7. Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent. Lorusso G, Vannini N, Sogno I, Generoso L, Garbisa S, Noonan DM, Albini A. Eur J Cancer. 2009 May;45(8):1474-84. doi: 10.1016/j.ejca.2009.01.014. Epub 2009 Feb 14. PMID: 19223175 8. The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent. Vannini N, Lorusso G, Cammarota R, Barberis M, Noonan DM, Sporn MB, Albini A. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3139-46. Epub 2007 Dec 7. PMID: 18065492

Members List