Klara Soukup

Institution: University of Lausanne | Ludwig Institute for Cancer Research

Address:

Centre Laboratoire d'Epalinges (CLE) Chemin des Boveresses 155 1066 Epalinges Switzerland

Email: klara.soukup@unil.ch

Group website: joycelab.org

Phone: +41 21 692 59 35

Research interests:

Tumor microenvironment and tumor immunology of metastatic cancers Currently focusing on brain metastases originating from breast and lung cancer and the involvement of immune cells in metastatic seeding and outgrowth in the brain PhD work: molecular regulation of dendritic cells in inflammation, auto- and tumor immunity

Selected publications:

Soukup K, Halfmann A, Dillinger B, Poyer F, Martin K, Blauensteiner B, Kauer M, Kuttke M, Schabbauer G, Dohnal AM (2017) Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response. Sci Rep 7(1):11746

Dillinger B, Ahmadi-Erber S, Soukup K, Halfmann A, Schrom S, Vanhove B, Steinberger P, Geyeregger R, Ladisch S, Dohnal AM (2017) CD28 blockade ex vivo induces alloantigen-specific immune tolerance but preserves T cell pathogen reactivity. Front Immunol 8:1152

Cong J, Wang Y, Zhang X, Zhang N, Liu L, Soukup K, Michelakos T, Hong T, DeLeo A, Cai L, Sabbatino F, Ferrone S, Lee H, Levina V, Fuchs B, Tanabe K, Lillemoe K, Ferrone C, Wang X (2017) A novel chemoradiation targeting stem and nonstem pancreatic cancer cells by repurposing disulfiram. Cancer Lett, in press doi: 10.1016/j.canlet.2017.08.028

Kuttke M, Sahin E, Pisoni J, Percig S, Vogel A, Kraemmer D, Hanzl L, Brunner JS, Paar H, Soukup K, Halfmann A, Dohnal AM, Steiner CW, Blüml S, Basilio J, Hochreiter B, Salzmann M, Hoesel B, Lametschwandtner G, Eferl R, Schmid JA, Schabbauer G (2016) Myeloid PTEN deficiency impairs tumor immune surveillance via immune checkpoint inhibition. Oncoimmunology 5(7): e1164918

Soukup K, Halfmann A, Le Bras M, Sahin E, Vittori S, Poyer F, Schuh C, Luger C, Niederreiter B, Haider T, Stoiber D, Blüml S, Schabbauer G, Kotlyarov A, Gaestel M, Felzmann T, Dohnal AM (2015) The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis. J Immunol 195(2): 541-52

Sahin E, Brunner JS, Kral JB, Kuttke M, Hanzl L, Datler H, Paar H, Neuwinger N, Saferding V, Zinser E, Halfmann A, Soukup K, Hainzl E, Lohmeyer T, Niederreiter B, Haider T, Dohnal AM, Krönke G, Blüml S, Schabbauer G (2015) Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis. J Immunol 195(6):2560-70

Soukup K, Wang X. (2015) Radiation Meets Immunotherapy - A Perfect Match in the Era of Combination Therapy? Int J Radiat Biol 91(4):299–305

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