Larissa Hillebrand

Institution: University of Freiburg


Stefan Meier Straße 17, 79104 Freiburg


Group website:

Phone: 0049-761-9604

Research interests:

Breast cancer, carcinoma progression, invasion and metastasis, proteases, proteolysis, tumor initiating cells, tumor microenvironment

Selected publications:

Ketterer S, Gomez‐Auli A, Hillebrand LE, Petrera A, Ketscher A, Reinheckel T. Inherited diseases caused by mutations in cathepsin protease genes. Review FEBS J. 2017 May; 284:1437‐54. Review. Hillebrand LE, Bengsch F, Hochrein J, Hülsdünker J, Bender J, Follo M, Busch H, Börries M, Reinheckel T. Proteolysis – a characteristic of tumor‐initiating cells in murine metastatic breast cancer. Oncotarget, 2016 Sep; 7(36):58244‐60. Gomez‐Auli A, Hillebrand LE, Biniossek ML, Peters C, Reinheckel T, Schilling O. Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers. Biochimie. 2016 Mar; 122:88–98. Tholen M, Hillebrand LE, Tholen S, Sedelmeier O, Arnold SJ, Reinheckel T. Out‐offrame start codons prevent translation of truncated nucleo‐cytosolic cathepsin L in vivo. Nature Communications. 2014 Sep; 290:15758‐69. Bengsch F, Buck A, Günther SC, Seiz JR, Tacke M, Pfeifer D, von Elverfeldt D, Sevenich L, Hillebrand LE, Kern U, Sameni M, Peters C, Sloane BF, Reinheckel T. Cell type‐dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression. Oncogene. 2014 Sep; 33:4474‐84.

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