Linsey Reavie

Institution: Friedrich Miescher Institute for Biomedical Research


Maulbeerstrasse 66 4058 Basel


Research interests:

Breast cancer patients do not succumb to their primary tumor but rather from the formation of metastases in distant organs. My research interests are centered around how epigenetics can instruct normal cell fate, induce the transition from normal to malignant transformation and from non-invasive to metastatic cancer states.

Selected publications:

1. *Reavie L, *Buckley SM, Loizou E, Takeshi S, Aranda-Orgilles B, Ndiaye-Lobry D, Ibrahim S, Nakayama KI, Aifantis I. Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia and progression. Cancer Cell. March 2013. Mar 18;23(3):362-75. 2. *Kelly Moran-Crusio, *Linsey Reavie, *Alan Shih, Omar Abdel-Wahab, Delphine Ndiaye-Lobry, Camille Lobry, Maria E. Figueroa, Aparna Vasanthakumar, Jay Patel, Xinyang Zhao, Fabiana Perna, Suveg Pandey, Jozef Madzo, Chunxiao Song, Qing Dai, Chuan He, Sherif Ibrahim, Miloslav Beran, Jiri Zavadil, Stephen D. Nimer, Ari Melnick, Lucy A. Godley, Iannis Aifantis, and Ross L. Levine. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell, July 2011. 12;20(1):11-24. 3.Reavie L, Della Gatta G, Crusio K, Aranda-Orgilles B, Buckley SM, Thompson B, Lee E, Gao J, Bredemeyer AL, Helmink BA, Zavadil J, Sleckman BP, Palomero T, Ferrando A, Aifantis I. Regulation of Hematopoietic Stem Cell Differentiation by a Single Ubiquitin Ligase-Substrate Complex. Nature Nature Immunology, March 2010; 11(3):207-15. 4.King B, Trimarchi T, Reavie L, Xu L, Mullenders J, Ntziachristos P, Aranda-Orgilles B, Perez- Garcia A, Shi J, Vakoc C, Sandy P, Shen SS, Ferrando A, Aifantis I. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell. June 2013 Mar;20;153(7):1552-66.

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