Manuele Giuseppe Muraro

Institution: University Hospital of Basel, Department of Biomedicine, Oncology Surgery


Lab 401 Hebelstrasse 20, CH-4031 Basel


Research interests:

Development of novel and more reliable 3D culture systems of primary tumor tissue and cancer cell lines as preclinical in vitro models for the discovery of cancer cells and cancer stem cell-targeted compounds of potential clinical relevance.

Selected publications:

CD133+, CD166+CD44+, and CD24+CD44+ phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal cancer cell lines. Muraro MG, Mele V, Däster S, Han J, Heberer M, Spagnoli GC, Iezzi G. Stem Cells Transl Med. 2012 Aug [PMID: 23197865]

Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-β. Mele V, Muraro MG, Calabrese D, Pfaff D, Amatruda N, Amicarella F, Kvinlaug B, Bocelli-Tyndall C, Martin I, Resink TJ, Heberer M, Oertli D, Terracciano L, Spagnoli GC, Iezzi G. Int J Cancer. 2013 Nov 10; [PMID: 24214914]

Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Lugli A, Iezzi G, Hostettler I, Muraro MG, Mele V, Tornillo L, Carafa V, Spagnoli G, Terracciano L, Zlobec I. Br J Cancer. 2010 Jul 27; [PMID: 20606680]

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