Nancy Hynes

Institution: FMI

Address:

Maulbeerstrasse 66, 4058 Basel

Email: nancy.hynes@fmi.ch

Group website: www.fmi.ch/hynes.n

Phone: 061 6978107

Research interests:

Metastasis research: models, pathways, novel proteins, targeting.
Estrogen receptor+ models
Receptor tyrosine kinases Signal transduction pathways

Selected publications:

B. Haenzi, O. Bonny, R. Masson, S. Lienhard, J.H. Dey, M. Kuro-o, N.E. Hynes (2014) Loss of Memo, a novel FGFR regulator, results in reduced lifespan. FASEB Journal 28: 327-336.

A. Gattelli, I. Nalvarte, A. Boulay, T. C. Roloff, M. Schreiber, N. Carragher, K.K. Macleod, M. Schlederer, S. Lienhard, L. Kenner, M. I. Torres-Arzayus, N. E. Hynes (2013) Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells. EMBO Mol Med 5:1335-1350.

A. Issa, J. W. Gill, M. R. Heideman, O. Sahin, S. Wiemann, J. H. Dey, N. E. Hynes. (2013) Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models. Breast Cancer Res. 2013 Jan 23;15(1):R8. [Epub ahead of print]

J. H. Dey, F. Bianchi, J. Voshol, D.Bonenfant, E.J. Oakeley, N.E. Hynes (2010) Targeting Fibroblast Growth Factor Receptors blocks PI3K/AKT signaling, induces apoptosis and impairs mammary tumor outgrowth and metastasis. Cancer Research 70:4151-62.

C. Heinrich, C. Keller, A. Boulay, M. Vecchi, M. Bianchi, R. Sack, S.Lienhard, S. Duss, J. Hofsteenge, N.E. Hynes (2010) Copine-III interacts with ErbB2 and promotes tumor cell migration. Oncogene 29: 1598-1610

B. Fayard, F. Bianchi, J. Dey, E. Moreno, S. Djaffer, N.E. Hynes*, D. Monard* (2009) Serine protease inhibitor Protease Nexin-1 controls mammary cancer metastasis through low density lipoprotein receptor-related protein-mediated matrix. metalloproteinase-9 expression. Cancer Res, 69: 5690-5698. *joint senior authors

Y.Matsuda, T.Schlange, E.J.Oakeley, A. Boulay, N.E. Hynes (2009) Wnt signaling enhances breast cancer cell motility and blockade of the Wnt pathway by sFRP1 suppresses MDA-MB-231 xenograft growth. Breast Cancer Research, 11:R32 doi:10.1186/bcr2317.

N.E.Hynes, P.W. Ingham, W.A. Lim, C. J. Marshall, J. Massague, T. Pawson (2013) Signaling change: signal transduction through the decades. Nature Rev Mol Cell Biol 14:393-398. doi:10.1038/nrm3581

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