Nicola Aceto

Institution: DBM – University of Basel

Address:

Mattenstrasse 28, 4058 Basel, Switzerland

Email: Nicola.Aceto@unibas.ch

Group website: www.cancermetastasislab.com

Phone: +41-79-936-3287

Research interests:

Circulating tumor cells, metastasis, single cell analysis, patient samples, mouse models

Selected publications:

Selected original publications:

1) Sarioglu FA*, Aceto N*, Kojic N, Donaldson MC, Zeinali M, Hamza B, Engstrom A, Zhu H, Sundaresan T, Miyamoto DT, Luo X, Bardia A, Wittner BS, Ramaswamy S, Shioda T, Ting DT, Stott SL, Kapur R, Maheswaran S, Haber DA and Toner M. “A microfluidic device for label-free, physical capture of circulating tumor cell clusters”. *Equal contribution. Nature Methods. 18 May 2015. PMID: 25984697

2) Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA and Maheswaran S. “Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis”. Cell. 2014 Aug 28. PMID: 25171411

3) Yu M, Bardia A, Aceto N, Bersani F, Madden MN, Donaldson MC, Desai R, Comaills V, Zheng Z, Brachtel E, Sgroi D, Kupur R, Getz G, Iafrate AJ, Benes C, Toner M, Maheswaran S and Haber DA. “Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility”. Science. 2014 Jul 11. PMID: 25013076

4) Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz P, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, and Bentires-Alj M. “Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop”. Nature Medicine. 2012 Mar 4. PMID: 22388088

5) Aceto N, Duss S, Macdonald G, Meyer DS, Roloff TC, Hynes NE and Bentires-Alj M. “Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8 autocrine secretion”. Breast Cancer Research. 2012 Oct 12. PMID: 23062209


6) Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF. “Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase”. Cell. 2011 Mar 4. PMID: 21376233

Selected reviews:

1) Aceto N, Toner M, Maheswaran S, Haber DA. “En route to metastasis: circulating tumor cell clusters and epithelial-to-mesenchymal transition”. Trends in Cancer, Cell press (inaugural issue). 2015 Sep 1.

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