Prof. Johanna Joyce

Institution: Ludwig Institute for Cancer Research, University of Lausanne

Address:

Department of Oncology University of Lausanne Office C305 Ch. des Boveresses 155 Epalinges 1066 Switzerland

Email: Johanna.Joyce@unil.ch

Group website: www.joycelab.org

Phone: 021 692 5937

Research interests:

My group is interested in the microenvironment in which a tumor arises and the critical influence that non-cancerous stromal cells can have on tumor progression, metastasis, and response to therapy. We investigate both positive and negative signals provided by the normal tissue stroma to the cancer cells, and how normal cells can be modified by the cancer cells to produce a variety of factors that enhance tumor malignancy. Our research mostly focuses on breast cancer and brain malignancies. My lab is also investigating the mechanisms underlying the contribution of the stromal microenvironment to therapeutic resistance, an important area of research that remains largely unexplored. We aim to ultimately apply this knowledge to the clinic and develop targeted therapies that disrupt these tumor-stromal interactions.

Selected publications:

Quail DF, Bowman RL, Akkari L, Quick ML, Schuhmacher AJ, Huse JT, Holland EC, Sutton JC and Joyce JA (2016). The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science 352: aad3018. Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue C, Brennan CW, Tabar V, Gutin PH and Joyce JA (2016). Macrophage ontogeny underlies differences in tumor-specific education in brain malignancies. Cell Reports Nov 9. pii: S2211-1247(16)31472-3. doi: 10.1016/j.celrep.2016.10.052. [Epub ahead of print]. Yan D, Wang H-W, Bowman RL and Joyce JA (2016). STAT3 and STAT6 signaling pathways synergize to promote cathepsin secretion from macrophages via IRE1a activation. Cell Reports 16: 2914-2927. Joyce JA and Fearon DF (2015). T cell exclusion, immune privilege and the tumor microenvironment. Science 348: 74-80. Klemm F and Joyce JA (2015). Microenvironmental regulation of therapeutic resistance in cancer. Trends in Cell Biology 25: 198-213. Sevenich L, Bowman R, Mason SD, Quail DF, Rapaport F, Elie BT, Brogi E Brastianos P, Hahn WC, Holsinger L, Massague J, Leslie CS and Joyce JA (2014). Analysis of tumour and stroma-supplied proteolytic networks reveals a brain metastasis-promoting role for cathepsin S. Nature Cell Biology 16: 876-888. Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail D, Olson OC, Quick M, Huse J, Teijeiro V, Setty M, Leslie C, Oei Y, Pedraza A, Zhang J, Brennan CW, Sutton JC, Holland EC, Daniel D and Joyce JA (2013). CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nature Medicine 19: 1264-1272. Quail DF and Joyce JA (2013). Microenvironmental regulation of tumor progression and metastasis. Nature Medicine 19: 1423-1437.

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