Ralph Tiedt

Institution: Novartis Insitutes for BioMedical Research

Address:

WKL-125.12.04 Klybeckstrasse 141 4057 Basel

Email: ralph.tiedt@novartis.com

Group website: postdoc.nibr.com/ralph-tiedt.html

Phone: +41 79 5721480

Research interests:

Drug discovery Translational research (patient selection, resistance, combinations) Epigenetics: DOT1L lung cancer: MET and EGFR inhibitors breast cancer: CDK4/6 inhibitors Exploratory immuno-oncology research (target and combination discovery)

Selected publications:

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia. Dafflon C, Craig VJ, Mereau, H, Schacher Engstler B, Hoffman G, Nigsch F, Gaulis S, Barys L, Ito M, Aguade Gorgorio J, Bornhauser B, Bourquin JP, Proske A, Stork-Fux C, Murakami M, Sellers WR, Hofmann F, Schwaller J, Tiedt R. Leukemia. 2017 Jun;31(6):1269-1277. Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth. Harbinski F, Craig VJ, Sanghavi S, Jeffery D, Liu L, Sheppard KA, Wagner S, Stamm C, Buness A, Chatenay-Rivauday C, Yao Y, He F, Lu CX, Guagnano V, Metz T, Finan PM, Hofmann F, Sellers WR, Porter JA, Myer VE, Graus-Porta D, Wilson CJ, Buckler A, Tiedt R. Cancer Discov. 2012 Oct;2(10):948-59 A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. Tiedt R, Degenkolbe E, Furet P, Appleton BA, Wagner S, Schoepfer J, Buck E, Ruddy DA, Monahan JE, Jones MD, Blank J, Haasen D, Drueckes P, Wartmann M, McCarthy C, Sellers WR, Hofmann F. Cancer Res. 2011 Aug 1;71(15):5255-64 Ratio of mutant JAK2-V617F to wild type Jak2 determines the MPD phenotypes in transgenic mice. Tiedt R, Hao-Shen H, Sobas MA, Looser R, Dirnhofer S, Schwaller J, Skoda RC. Blood. 2008 Apr 15;111(8):3931-40 A gain-of-function mutation of JAK2 in myeloproliferative disorders. Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC. N Engl J Med. 2005 Apr 28;352(17):1779-90

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