Salvatrore Piscuoglio

Institution: University Hospital Basel / Institute of Pathology

Address:

Schönbeinstrasse 40 CH-4031 Basel

Email: Salvatore.Piscuoglio@usb.ch

Research interests:

Cancer Genomics, Inter-/Intra- tumor genetic heterogeneity and personalized medicine.

Selected publications:

Piscuoglio S, Ng KYC, Murray M, Martelotto LG, Sakr RA, Bidard FC, Eberle CA, Guerini Rocco E, Fusco N, De Mattos-Arruda L, Hicks J, Baslan T, King TA, Brogi E, Norton L, Weigelt B, Hudis CA & Reis-Filho JS. The Genomic Landscape of Male Breast Cancers. (Clinical Cancer Research; In Press) Piscuoglio S, Ng CK, Murray M, Burke KA, Edelweiss M, Geyer FC, Macedo GS, Inagaki A, Papanastasiou AD, Martelotto LG, Marchio C, Lim RS, Ioris RA, Nahar PK, Bruijn ID, Smyth L, Akram M, Ross D, Petrini JH, Norton L, Solit DB, Baselga J, Brogi E, Ladanyi M, Weigelt B, Reis-Filho JS. Massively parallel sequencing of phyllodes tumours of the breast reveals actionable mutations, and TERT promoter hotspot mutations and TERT gene amplification as likely drivers of progression. J Pathol. 2016 Mar;238(4):508-18. doi: 10.1002/path.4672. Epub 2016 Jan 25. Sakr RA, Schizas M, Scarpa-Carniello JV, Ng KYC, Piscuoglio S, Giri D, Andrade VP, De Brot M, Lim R, Towers R, Weigelt B, Reis-Filho JS, King TA. Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: repertoire of somatic genetic alterations and clonal relationships. Mol Oncol. 2016 Feb;10(2):360-70. doi: 10.1016/j.molonc.2015.11.001 Guerini-Rocco E*, Piscuoglio S*, Ng KYC, De Filippo M, Geyer FC, Eberle CA, Akram M, Fusco N, Ichihara S, Sakr RA, Yatabe Y, Vincent-Salomon A, Rakha EA, Ellis IO, Wen YH, Weigelt B, Schnitt SJ and Reis-Filho JS. Microglandular adenosis associated with triple-negative breast cancer is a neoplastic lesion of triple-negative phenotype harboring TP53 somatic mutations. J Pathol. 2016 Jan 25. doi: 10.1002/path.4691 (Equally contributed) Guerini-Rocco E1*, Hodi Z*, Piscuoglio S*, Ng KYC*, Rakha EA, Schultheis AM, Marchiò C, da Cruz Paula A, De Filippo MR, Martelotto LG, De Mattos-Arruda L, Edelweiss M, Jungbluth AA, Fusco N, Norton L, Weigelt B, Ellis IO and Reis-Filho JS. The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: an exploratory, hypothesis-generating study. J Pathol. 2015 May 23 (Equally contributed) Ng KYC *, Martelotto LG *, Gauthier A*, Wen HC*, Piscuoglio S, Lim RS, Cowell C, Wilkerson PM, Wai, Rodrigues PN, Arnould L, Geyer FC, Bromberg FE, Lacroix-Triki M, Penault-Llorca M, Giard S, Sastre-Garau X, Natrajan R, Norton L, Cottu P, Weigelt B*§, Vincent-Salomon A*§, Reis-Filho JS*§. Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification. Genome Biol. 2015 May 22;16(1):107 Weinreb I*, Piscuoglio S*, Martelotto LG, Waggott D, Ng CK, Perez-Ordonez B, Harding NJ, Alfaro J, Chu KC, Viale A, Fusco N, da Cruz Paula A, Marchio C, Sakr RA, Lim R, Thompson LD, Chiosea SI, Seethala RR, Skalova A, Stelow EB, Fonseca I, Assaad A, How C, Wang J, de Borja R, Chan-Seng-Yue M, Howlett CJ, Nichols AC, Wen YH, Katabi N, Buchner N, Mullen L, Kislinger T, Wouters BG, Liu FF, Norton L, McPherson JD, Rubin BP, Clarke BA, Weigelt B, Boutros PC, Reis-Filho JS. Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. Nat Genet. 2014 Nov;46(11):1166-9 (Equally contributed) Piscuoglio S, Ng C, Martelotto LG, Eberle CA, Cowell CF, Natrajan R, Bidard FC, De Mattos-Arruda L, Wilkerson P, Mariani O, Vincent-Salomon A, Weigelt B, Reis-Filho JS. Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast. Mol Oncol. 2014 Jun 26. S1574-7891(14)00135-5

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