Saskia Brachmann

Institution: NIBR ONC


Klybeckstr 121 WKL125.6.20 4002 Basel


Phone: +41 61 696 4063

Research interests:

Cancer Heterogeneity
Metastasis PI3K GTPases
Signal transduction
Target ID and Validation

Selected publications:

Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations. Brachmann SM, et al. (Novartis) Mol Cancer Ther. 2012 Aug;11(8):1747-57.

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells. Brachmann SM, et al. (Novartis) Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22299-304. doi: 10.1073/pnas.0905152106. Epub 2009 Dec 10.

Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement. Brachmann SM, Yballe CM, Innocenti M, Deane JA, Fruman DA, Thomas SM, Cantley LC. Mol Cell Biol. 2005 Apr;25(7):2593-606.

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Brachmann SM, Ueki K, Engelman JA, Kahn RC, Cantley LC. Mol Cell Biol. 2005 Mar;25(5):1596-607.

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