Shany Koren

Institution: Friedrich Miescher Institute for Biomedical Research


Maulbeerstrasse 66, 4058 Basel, Switzerland


Group website:

Research interests:

breast cell fate specification, breast cancer, tumor heterogeneity

Selected publications:

PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.Koren S, Reavie L, Couto JP, De Silva D, Stadler MB, Roloff T, Britschgi A, Eichlisberger T, Kohler H, Aina O, Cardiff RD, Bentires-Alj M. Nature. 2015 Sep 3;525(7567):114-8. doi: 10.1038/nature14669. Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R. Meyer DS*, Koren S*, Leroy C, Brinkhaus H, Müller U, Klebba I, Müller M, Cardiff RD, Bentires-Alj M.Oncogenesis. 2013 Sep 30;2:e74. doi: 10.1038/oncsis.2013.38. Mouse models of PIK3CA mutations: one mutation initiates heterogeneous mammary tumors. Koren S, Bentires-Alj M.FEBS J. 2013 Jun;280(12):2758-65. doi: 10.1111/febs.12175.

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