Thomas Bohnacker

Institution: Departement of Biomedicine, University of Basel

Address:

Departement of Biomedicine Mattenstrasse 28 4058 Basel Switzerland

Email: thomas.bohnacker@unibas.ch

Phone: 0041612075045

Research interests:

PI3K, oncology, immunology, drug development, cell signaling

Selected publications:

“Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention” Thomas Bohnacker, Andrea Prota, Florent Beaufils, John Burke, Anna Melone, Alison Inglis, Denise Rageot, Alexander Sele, Vladimir Cmiljanovic, Natasa Cmiljanovic, Katja Bargsten, Amol Aher, Anna Akhmanova, J. Fernando Diaz, Doriano Fabbro, Marketa Zvelebil, Roger Williams, Michel Steinmetz, and Matthias Wymann, Nat Commun. 2017 Mar 9;8:14683. doi: 10.1038/ncomms14683. “Transient Targeting of PI3K Acts as a Roadblock in Mast Cells' Route to Allergy” Bohnacker Thomas*, Collmann Emilie*, Marone Romina, Dawson Janet, Rehberg Markus, Stringer Rowan, Krombach Fritz, Burkhart Christoph, Hirsch Emilio, Hollingworth J Gregory, Thomas Matthew, Matthias P. Wymann. *equal contribution. J Allergy Clin Immunol. 2013 Oct;132(4):959-68.doi:10.1016/ j.jaci.2013. 03.008 “PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells” Bohnacker T, Marone R, Collmann E, Calvez R, Hirsch E, Wymann MP. Science Signaling. 2009 Jun 9;2(74):ra27. “PQR309 – a Potent, Brain-Penetrant, Orally Bioavailable, pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology” Florent Beaufils*, Natasa Cmiljanovic*, Vladimir Cmiljanovic*, Thomas Bohnacker, Anna Melone, Romina Marone, Eileen Jackson, Xuxiao Zhang, Alexander Sele, Chiara Borsari, Jürgen Mestan, Paul Hebeisen, Petra Hillmann, Bernd Giese, Marketa Zvelebil, Doriano Fabbro, Roger L. Williams, Denise Rageot, Matthias P. Wymann (* joint 1st authors, J Med Chem. 2017 Aug 22. doi: 10.1021/ acs.jmedchem.7b00930.) “PKCbeta Phosphorylates PI3Kgamma to Activate It and Release It from GPCR Control” Romy Walser, John E. Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L. Williams, Muriel Laffargue, Matthias P. Wymann. PLoS Biology 2013 Jun;11(6):e1001587. doi: 10.1371/journal.pbio.1001587. "Ras is an indispensable co-regulator of the class IB phosphoinositide 3-kinase p87/p110gamma" Barbara Kurig, Aliaksei Shymanets, Thomas Bohnacker, Prajwal, Carsten Brock, Mohammad Reza Ahmadian, Michael Schaefer, Antje Gohla, Christian Harteneck, Matthias P. Wymann, Elisabeth Jeanclos, and Bernd Nürnberg. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20312-7. “Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors” Marone R, Erhart D, Mertz AC, Bohnacker T, Schnell C, Cmiljanovic V, Stauffer F, Garcia-Echeverria C, Giese B, Maira SM, Wymann MP. Mol Cancer Res. 2009 Apr;7(4):601-13.

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