Thomas Reinheckel

Institution: Institute of Molecular Medicine and Cell Research, Medical Faculty, University of Freiburg, Germany

Address:

Stefan Meier Str. 17 79104 Freiburg, Germany

Email: thomas.reinheckel@mol-med.uni-freiburg.de

Group website: www.mol-med.uni-freiburg.de/mom-en/reinheckel/index_html?set_language=en

Phone: +49 761 203 9606

Research interests:

In this lab we aim to understand protease regulation and function in physiological processes but also in a variety of diseases. In this regard protease-driven carcinoma progression and metastasis are in the focus of our research. To this end we develop models for selective inhibition of protease activities thereby interfering with disease progression.

Selected publications:

Tholen, M., Hillebrand, L. E., Tholen, S., Sedelmeier, O., Arnold, S. J. & Reinheckel, T. Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo. Nat Commun 2014/5: 4931. D.O.I.: 10.1038/ncomms5931 Akkari, L., Gocheva, V., Kester, J. C., Hunter, K. E., Quick, M. L., Sevenich, L., Wang, H. W., Peters, C., Tang, L. H., Klimstra, D. S., Reinheckel, T. & Joyce, J. A. Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Genes Dev 2014/28: 2134-50. D.O.I.: 10.1101/gad.249599.114 Bengsch, F., Buck, A., Gunther, S. C., Seiz, J. R., Tacke, M., Pfeifer, D., Von Elverfeldt, D., Sevenich, L., Hillebrand, L. E., Kern, U., Sameni, M., Peters, C., Sloane, B. F. & Reinheckel, T. Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression. Oncogene 2014/33: 4474-84. D.O.I.: 10.1038/onc.2013.395 Reiser, J., Adair, B. & Reinheckel, T. Specialized roles for cysteine cathepsins in health and disease. J Clin Invest 2010/120: 3421-31. D.O.I.: 10.1172/JCI42918 Sevenich, L., Schurigt, U., Sachse, K., Gajda, M., Werner, F., Muller, S., Vasiljeva, O., Schwinde, A., Klemm, N., Deussing, J., Peters, C. & Reinheckel, T. Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A 2010/107: 2497-502. D.O.I.: 10.1073/pnas.0907240107 Urbich, C., Heeschen, C., Aicher, A., Sasaki, K., Bruhl, T., Farhadi, M. R., Vajkoczy, P., Hofmann, W. K., Peters, C., Pennacchio, L. A., Abolmaali, N. D., Chavakis, E., Reinheckel, T., Zeiher, A. M. & Dimmeler, S. Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med 2005/11: 206-13. D.O.I.: 10.1038/nm1182 Vasiljeva, O., Papazoglou, A., Kruger, A., Brodoefel, H., Korovin, M., Deussing, J., Augustin, N., Nielsen, B. S., Almholt, K., Bogyo, M., Peters, C. & Reinheckel, T. Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res 2006/66: 5242-50. D.O.I.: 10.1158/0008-5472.CAN-05-4463 Stypmann, J., Glaser, K., Roth, W., Tobin, D. J., Petermann, I., Matthias, R., Monnig, G., Haverkamp, W., Breithardt, G., Schmahl, W., Peters, C. & Reinheckel, T. Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc Natl Acad Sci U S A 2002/99: 6234-9. D.O.I.: 10.1073/pnas.092637699

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