Vida Vafaizadeh

Institution: Department of Biomedicine, University of Basel

Address:

Mattenstrasse 28 4058 Basel

Email: vida.vafaizadeh@unibas.ch

Group website: biomedizin.unibas.ch/nc/research/research-group-details/home/researchgroup/tumor-biology/

Phone: 061 2075053

Research interests:

Canonical and non-canonical Wnt signaling in breast carcinogenesis, epithelial-mesenchymal transition (EMT), TGFb signaling, Jak/Stat signaling, mammary gland development

Selected publications:

1) Vafaizadeh V, Klemmt P, Brendel C, Weber K, Doebele C, Britt K, Grez M, Fehse B, Desriviéres S, Groner B. (2010) Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation. Stem Cells. 2010 May;28(5):928-38. 2) Ucar A, Vafaizadeh V, Jarry H, Fiedler J, Klemmt PA, Thum T, Groner B, Chowdhury K. miR-212 and miR-132 are required for epithelial stromal interactions necessary for mouse mammary gland development. Nat Genet. 2010 Dec;42(12):1101-8. 3) Vafaizadeh V, Klemmt PA, Groner B. Stat5 assumes distinct functions inmammary gland development and mammary tumor formation. Front Biosci. 2012, 1;17:1232-50. 4) Vafaizadeh V, Graab U, Darvishi T, Machado R, Groner B. Transforming growthfactor β signaling regulates the invasiveness of normal mammary epithelial cells and the metastasis formation of tumor cells. Horm Mol Biol Clin Investig. 2012 Jun;10(1):227-39. 5) Werner S, Frey S, Riethdorf S, Schulze C, Alawi M, Kling L, Vafaizadeh V, Sauter G, Terracciano L, Schumacher U, Pantel K, Assmann V. Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer. J Biol Chem. 2013 Aug 9;288(32):22993-3008. 6) Xiang M, Birkbak NJ, Vafaizadeh V, Walker SR, Yeh JE, Liu S, Kroll Y, Boldin M, Taganov K, Groner B, Richardson AL, Frank DA. STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes. Sci Signal. 2014 Jan 28;7(310):ra11. 7) Toniolo PA, Liu S, Yeh JE, Moraes-Vieira PM, Walker SR, Vafaizadeh V, Barbuto JA, Frank DA. Inhibiting STAT5 by the BET bromodomain inhibitor JQ1 disrupts human dendritic cell maturation. J Immunol. 2015 Apr 1;194(7):3180-90. 8) Schmithals C, Köberle V, Korkusuz H, Pleli T, Kakoschky B, Augusto EA, Ibrahim AA, Arencibia JM, Vafaizadeh V, Groner B, Korf HW, Kronenberger B, Zeuzem S, Vogl TJ, Waidmann O, Piiper A. Improving Drug Penetrability with iRGD Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma. Cancer Res. 2015 Aug 1;75(15):3147-54.

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